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Bending the Curve Trial by Trial
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Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide

N = 261

Population
Men with disseminated germ-cell tumours; 244 of 261 were evaluable for response, 157 of them with high tumour volume
Design
Randomised clinical trial in disseminated germ-cell tumours: etoposide substituted for vinblastine in a cisplatin and bleomycin regimen in half of the patients. Phase, stratification and cooperative group are not stated in the PubMed abstract.
Arms
  • PVB (control): Cisplatin, vinblastine and bleomycin
  • BEP (experimental): Cisplatin, etoposide and bleomycin
People
Williams SD, senior author Loehrer PJ
Δ Disease-free status after treatment+9 pointsΔ Disease-free status after treatment+16 points
Show the numbers
Results reported for Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide
EndpointAnalysisBEPPVBEffect
Disease-free status after treatmentPatients evaluable for response (244 of 261)Disease-free with or without subsequent surgeryprimaryWilliams 198783%74%P=not significantReported as 'P not significant' in the abstract; no exact p-value given. Arm sizes are not stated in the abstract.
Disease-free status after treatmentPatients with high tumour volume (157)Disease-free with or without subsequent surgeryexploratoryWilliams 198777%61%P<0.05Subgroup defined by tumour volume. The abstract does not say whether this subgroup was prespecified.
Results reported for Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide
EndpointAnalysisBEPPVBEffect
Disease-free status after treatmentPatients evaluable for response (244 of 261)Disease-free with or without subsequent surgeryprimaryWilliams 198783%74%P=not significantReported as 'P not significant' in the abstract; no exact p-value given. Arm sizes are not stated in the abstract.
Disease-free status after treatmentPatients with high tumour volume (157)Disease-free with or without subsequent surgeryexploratoryWilliams 198777%61%P<0.05Subgroup defined by tumour volume. The abstract does not say whether this subgroup was prespecified.
Primary publication: Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316(23):1435-40. PubMedDOI

Appears in

Sources

  1. Williams SD, Birch R, Einhorn LH, Irwin L, Greco FA, Loehrer PJ. Treatment of disseminated germ-cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med. 1987;316(23):1435-40.

    PubMedDOI