UKW3
Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms' tumour (UKW3), UK Children's Cancer Study Group
N = 205
- Population
- Children with newly diagnosed non-metastatic renal tumours, 186 of 205 with Wilms histologies
- Design
- Randomised trial, 1991 to 2001: 205 patients with newly diagnosed non-metastatic renal tumours, of which 186 had Wilms histologies, were randomly assigned to immediate surgery or to 6 weeks of preoperative chemotherapy with vincristine and actinomycin D and then delayed surgery. Both groups received postoperative chemotherapy according to tumour stage and histology determined at nephrectomy.
- Arms
- Immediate nephrectomy (control): Immediate surgery, then postoperative chemotherapy by stage and histology
- Preoperative chemotherapy, delayed surgery (experimental): 6 weeks of preoperative vincristine and actinomycin D, delayed surgery, then postoperative chemotherapy by stage and histology
- People
- Mitchell C, UK Children's Cancer Study Group
Δ Stage III at nephrectomy−20 points
Show the numbers
| Endpoint | Analysis | Preoperative chemotherapy, delayed surgery | Immediate nephrectomy | Effect |
|---|---|---|---|---|
| Stage III at nephrectomyPatients with Wilms histologies (186 of 205 randomised) | primaryMitchell 2006 | 9.8% | 29.8% | P=0.008P is the chi-squared test for trend (7.02) across the whole stage I, II and III distribution, not for stage III alone. Delayed versus immediate surgery as printed: stage I 65.2% v 54.3%; stage II 23.9% v 14.9%. |
| Endpoint | Analysis | Preoperative chemotherapy, delayed surgery | Immediate nephrectomy | Effect |
|---|---|---|---|---|
| Stage III at nephrectomyPatients with Wilms histologies (186 of 205 randomised) | primaryMitchell 2006 | 9.8% | 29.8% | P=0.008P is the chi-squared test for trend (7.02) across the whole stage I, II and III distribution, not for stage III alone. Delayed versus immediate surgery as printed: stage I 65.2% v 54.3%; stage II 23.9% v 14.9%. |
Appears in
Sources
Mitchell C, Pritchard-Jones K, Shannon R, Hutton C, Stevens S, Machin D, et al. Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms' tumour: results of a randomised trial (UKW3) by the UK Children's Cancer Study Group. Eur J Cancer. 2006;42(15):2554-62.