A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials
Phase meta-analysisN = 1,476
- Population
- Patients with stage Ta T1 bladder cancer, single and multiple tumours, in 7 randomised trials.
- Design
- Meta-analysis of published randomised trials comparing transurethral resection alone with resection plus one immediate instillation of chemotherapy (epirubicin, mitomycin C, thiotepa or pirarubicin): 7 trials, recurrence information on 1476 patients.
- Arms
- Resection plus one immediate instillation (experimental): Transurethral resection plus one immediate postoperative instillation of chemotherapy
- Resection alone (control): Transurethral resection alone
- People
- Sylvester RJ
Δ Recurrence after resection−11.7 points
Show the numbers
| Endpoint | Analysis | Resection plus one immediate instillation | Resection alone | Effect |
|---|---|---|---|---|
| Recurrence after resectionPooled patients with recurrence information (7 trials) | finalmedian follow-up 3.4 yearsSylvester 2004 | 36.7% | 48.4% | P<0.0001267 of 728 versus 362 of 748; odds ratio 0.61 (a 39% decrease in the odds of recurrence; no confidence interval in the abstract). Maximum follow-up 14.5 years. After one instillation, 65.2% of patients with multiple tumours had recurrence versus 35.8% of those with single tumours. |
| Endpoint | Analysis | Resection plus one immediate instillation | Resection alone | Effect |
|---|---|---|---|---|
| Recurrence after resectionPooled patients with recurrence information (7 trials) | finalmedian follow-up 3.4 yearsSylvester 2004 | 36.7% | 48.4% | P<0.0001267 of 728 versus 362 of 748; odds ratio 0.61 (a 39% decrease in the odds of recurrence; no confidence interval in the abstract). Maximum follow-up 14.5 years. After one instillation, 65.2% of patients with multiple tumours had recurrence versus 35.8% of those with single tumours. |
Appears in
Sources
Sylvester RJ, Oosterlinck W, van der Meijden AP. A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of published results of randomized clinical trials. J Urol. 2004;171(6 Pt 1):2186-90, quiz 2435.