SIOP randomised trial of preoperative radiotherapy plus chemotherapy versus preoperative chemotherapy in Wilms' tumour (patients registered January 1977 to July 1979)
N = 164
- Population
- Children with histologically proven Wilms tumour (nephroblastoma) registered at SIOP centres and eligible for the trial
- Design
- SIOP controlled clinical trial: of 397 histologically proven cases of Wilms tumour registered at 34 centres between January 1977 and July 1979, 164 were eligible and randomised to preoperative radiotherapy and chemotherapy (group R, 76 patients) or preoperative chemotherapy (group C, 88 patients). Outcomes named in the abstract: surgical tumour ruptures and local tumour extent at pathological examination; survival and recurrence-free survival also considered. The trial number is not stated in the abstract.
- Arms
- Preoperative radiotherapy plus chemotherapy (group R) (control, n = 76): Preoperative radiotherapy and chemotherapy
- Preoperative chemotherapy (group C) (experimental, n = 88): Preoperative chemotherapy
- People
- Lemerle J, International Society of Paediatric Oncology (SIOP)