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Bending the Curve Trial by Trial
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SCORE

SCORE: Italian randomised controlled trial of once-only sigmoidoscopy in colorectal cancer screening

Population
Men and women aged 55 to 64 years, randomly selected from six centres in Italy, who were eligible and interested in screening.
Design
Randomised controlled trial in six Italian centres. A questionnaire was mailed to 236,568 men and women aged 55 to 64; of 56,532 respondents, those interested and eligible were randomly assigned between June 1995 and May 1999 to an invitation for flexible sigmoidoscopy or to a control group (no further contact). Intention-to-treat and per-protocol analyses were done; the per-protocol analysis was adjusted for non-compliance.
Arms
  • Invited to flexible sigmoidoscopy (experimental, n = 17,148): Invitation to once-only flexible sigmoidoscopy
  • Control (control, n = 17,144): No further contact
People
Segnan N
Primary publication: Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M, et al. Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial--SCORE. J Natl Cancer Inst. 2011;103(17):1310-22. PubMedDOI

Appears in

Sources

  1. Segnan N, Armaroli P, Bonelli L, Risio M, Sciallero S, Zappa M, et al. Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial--SCORE. J Natl Cancer Inst. 2011;103(17):1310-22.

    PubMedDOI