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Prognostic factors and long-term results after thymoma resection: a series of 307 patients

Phase observationalN = 307

Population
307 patients operated for thymoma; 196 had myasthenia gravis
Design
Case series of 307 patients who underwent an operation for thymoma (196 with myasthenia gravis), analysed for the prognostic value of Masaoka clinical stage, completeness of resection, histologic classification (Verley-Hollmann), history of myasthenia gravis and postoperative radiotherapy. Stages: I 135, II 70, III 83, IV 19. Resection: complete 260, incomplete 30, biopsy 17. Radiotherapy was given mainly for invasive or metastatic thymoma. Mean follow-up 8 years; eight patients were lost to follow-up. Univariate and multivariate analyses. The abstract does not state whether the series was retrospective or from one centre (first author's affiliation: Marie Lannelongue Hospital, Le Plessis-Robinson, France).
Arms
  • All patients operated for thymoma (experimental, n = 307): Surgery (complete, incomplete or biopsy only); postoperative radiotherapy mainly in invasive or metastatic thymoma
People
Regnard JF, senior author Levasseur P
Show the numbers
Results reported for Prognostic factors and long-term results after thymoma resection: a series of 307 patients
EndpointAnalysisAll patients operated for thymomaControlEffect
OSAll 307 operated patientsfinalRegnard 199667% at 10 y; 57% at 15 y—Overall 10- and 15-year survival as printed; not stratified in the abstract.
Results reported for Prognostic factors and long-term results after thymoma resection: a series of 307 patients
EndpointAnalysisAll patients operated for thymomaControlEffect
OSAll 307 operated patientsfinalRegnard 199667% at 10 y; 57% at 15 y—Overall 10- and 15-year survival as printed; not stratified in the abstract.
Illustrative — modelled from reported values, not trial data. OS, final.
0%25%50%75%100%050100150Months (modelled)
  • All patients operated for thymoma (experimental)
Data table (modelled values)
MonthsAll patients operated for thymoma
0100.0%
4985.9%
9772.5%
14662.2%
19457.0%
Primary publication: Regnard JF, Magdeleinat P, Dromer C, Dulmet E, de Montpreville V, Levi JF, et al. Prognostic factors and long-term results after thymoma resection: a series of 307 patients. J Thorac Cardiovasc Surg. 1996;112(2):376-84. PubMedDOI

Appears in

Sources

  1. Regnard JF, Magdeleinat P, Dromer C, Dulmet E, de Montpreville V, Levi JF, et al. Prognostic factors and long-term results after thymoma resection: a series of 307 patients. J Thorac Cardiovasc Surg. 1996;112(2):376-84.

    PubMedDOI