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Bending the Curve Trial by Trial
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Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission: individual-patient-data meta-analysis of seven trials

Phase meta-analysisN = 987

Population
Patients with small-cell lung cancer in complete remission
Design
Meta-analysis of individual patient data from seven trials comparing prophylactic cranial irradiation (PCI) with no PCI. The main endpoint was survival. The abstract does not state the stage of disease.
Primary endpoint
OS
Arms
  • Prophylactic cranial irradiation (experimental): Prophylactic cranial irradiation (total doses in the pooled trials: 8 Gy, 24 to 25 Gy, 30 Gy, 36 to 40 Gy)
  • No prophylactic cranial irradiation (control): No prophylactic cranial irradiation
People
Aupérin A, senior author Aisner J, Prophylactic Cranial Irradiation Overview Collaborative Group
Δ 36-month OS+5.4 points
Show the numbers
Results reported for Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission: individual-patient-data meta-analysis of seven trials
EndpointAnalysisProphylactic cranial irradiationNo prophylactic cranial irradiationEffect
OS987 patients in seven trials (individual patient data)primaryAupérin 199920.7% at 3 y15.3% at 3 yP=0.01Relative risk of death 0.84 (95% CI 0.73 to 0.97); this is a relative risk as published, not entered as a hazard ratio. Survival at 3 years: 20.7% with PCI vs 15.3% without.
Results reported for Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission: individual-patient-data meta-analysis of seven trials
EndpointAnalysisProphylactic cranial irradiationNo prophylactic cranial irradiationEffect
OS987 patients in seven trials (individual patient data)primaryAupérin 199920.7% at 3 y15.3% at 3 yP=0.01Relative risk of death 0.84 (95% CI 0.73 to 0.97); this is a relative risk as published, not entered as a hazard ratio. Survival at 3 years: 20.7% with PCI vs 15.3% without.
Primary publication: Aupérin A, Arriagada R, Pignon JP, Le Péchoux C, Gregor A, Stephens RJ, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med. 1999;341(7):476-84. PubMedDOI

Appears in

Sources

  1. Aupérin A, Arriagada R, Pignon JP, Le Péchoux C, Gregor A, Stephens RJ, et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med. 1999;341(7):476-84.

    PubMedDOI