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NWTS-1

National Wilms' Tumor Study 1 (NWTS-1)

N = 606

Population
Children with Wilms tumour from group I (tumour confined to the kidney and totally removed) to group IV (remote metastases at diagnosis)
Design
Cooperative-group study begun in 1969: 606 children registered, 359 randomised. Randomised comparisons named in the abstract: postoperative radiotherapy or none after nephrectomy with 15 months of maintenance actinomycin D (group I, under 2 years of age); actinomycin D plus vincristine versus either drug alone (groups II and III, all given postoperative radiotherapy); preoperative vincristine or none added to postoperative radiotherapy, actinomycin D and vincristine (group IV). The abstract gives no relapse or survival figures.
Arms
  • Actinomycin D alone (control): Actinomycin D alone, with postoperative radiotherapy (groups II and III)
  • Vincristine alone (control): Vincristine alone, with postoperative radiotherapy (groups II and III)
  • Actinomycin D plus vincristine (experimental): Actinomycin D combined with vincristine, with postoperative radiotherapy (groups II and III)
People
D'Angio GJ, National Wilms' Tumor Study
Primary publication: D'Angio GJ, Evans AE, Breslow N, Beckwith B, Bishop H, Feigl P, et al. The treatment of Wilms' tumor: Results of the national Wilms' tumor study. Cancer. 1976;38(2):633-46. PubMedDOI

Appears in

Sources

  1. D'Angio GJ, Evans AE, Breslow N, Beckwith B, Bishop H, Feigl P, et al. The treatment of Wilms' tumor: Results of the national Wilms' tumor study. Cancer. 1976;38(2):633-46.

    PubMedDOI