Nottingham randomised controlled trial of faecal-occult-blood screening for colorectal cancer
N = 152,850
- Population
- People aged 45 to 74 years living in the Nottingham area, UK.
- Design
- Randomised trial; 152,850 people aged 45 to 74 in the Nottingham area recruited between February 1981 and January 1991 were allocated to faecal-occult-blood screening or no screening (controls were not told about the study). Haemoccult test kits were sent by family doctors, tests were not rehydrated, and people with a negative first test were invited again every two years; screening ended in February 1995 after three to six offers. People with a positive test were offered colonoscopy.
- Primary endpoint
- Colorectal cancer mortality
- Arms
- Screening group (experimental, n = 76,466): Haemoccult faecal-occult-blood test every two years, not rehydrated
- Control group (control, n = 76,384): No screening; not told about the study
- People
- Hardcastle JD