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Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium

N = 25

Population
Patients with transitional cell carcinoma of the urothelial tract
Design
Single-arm series of 25 patients given monthly M-VAC cycles: methotrexate 30 mg/m2, then 24 hours later vinblastine 3 mg/m2, doxorubicin 30 mg/m2 and cisplatin 70 mg/m2, with repeat vinblastine and methotrexate on days 15 and 22.
Arms
  • M-VAC (experimental, n = 25): Methotrexate, vinblastine, doxorubicin and cisplatin in monthly cycles
People
Sternberg CN
Show the numbers
Results reported for Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium
EndpointAnalysisM-VACControlEffect
Complete response rate24 patients with bidimensionally measurable indicator lesionsprimarySternberg 198550% (30–70%)—Six of the 12 complete clinical remissions had pathological confirmation; median duration of response was not yet reached at 9.5+ months (range 4.5+ to 16+).
Results reported for Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium
EndpointAnalysisM-VACControlEffect
Complete response rate24 patients with bidimensionally measurable indicator lesionsprimarySternberg 198550% (30–70%)—Six of the 12 complete clinical remissions had pathological confirmation; median duration of response was not yet reached at 9.5+ months (range 4.5+ to 16+).
Primary publication: Sternberg CN, Yagoda A, Scher HI, Watson RC, Ahmed T, Weiselberg LR, et al. Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol. 1985;133(3):403-7. PubMedDOI

Appears in

Sources

  1. Sternberg CN, Yagoda A, Scher HI, Watson RC, Ahmed T, Weiselberg LR, et al. Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol. 1985;133(3):403-7.

    PubMedDOI