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Bending the Curve Trial by Trial
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The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity

N = 36

Population
Patients with nonmetastatic high-grade osteosarcoma of the extremity after definitive surgery
Design
Randomised controlled trial with concurrent controls: after definitive surgery, 36 patients were randomly assigned to intensive multi-agent adjuvant chemotherapy or to observation. 77 additional patients who declined randomisation chose observation or chemotherapy and were reported alongside.
Arms
  • Observation (control): No adjuvant treatment after surgery
  • Adjuvant chemotherapy (experimental): Intensive multi-agent adjuvant chemotherapy (agents not named in the abstract)
People
Link MP
Δ 24-month RFS+49 points
Show the numbers
Results reported for The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity
EndpointAnalysisAdjuvant chemotherapyObservationEffect
RFSPatients randomised after definitive surgery (36)primaryLink 198666% at 2 y17% at 2 yP<0.001Two-year actuarial relapse-free survival. Similar results were reported in 77 additional non-randomised patients.
Results reported for The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity
EndpointAnalysisAdjuvant chemotherapyObservationEffect
RFSPatients randomised after definitive surgery (36)primaryLink 198666% at 2 y17% at 2 yP<0.001Two-year actuarial relapse-free survival. Similar results were reported in 77 additional non-randomised patients.
Primary publication: Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314(25):1600-6. PubMedDOI

Appears in

Sources

  1. Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB, et al. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med. 1986;314(25):1600-6.

    PubMedDOI