IFM 94
Single versus double autologous stem-cell transplantation for multiple myeloma
N = 399
- Population
- Previously untreated patients with multiple myeloma under 60 years of age.
- Design
- Randomised trial in 399 previously untreated patients under 60 years of age with myeloma, assigned at diagnosis to high-dose chemotherapy followed by a single or a double autologous stem-cell transplantation.
- Arms
- Single transplant (control): High-dose chemotherapy with one autologous stem-cell transplantation
- Double transplant (experimental): High-dose chemotherapy with two successive autologous stem-cell transplantations
- People
- Attal M
Δ CR or VGPR rate+8 pointsΔ 84-month EFS+10 pointsΔ 84-month OS+21 points
Show the numbers
| Endpoint | Analysis | Double transplant | Single transplant | Effect |
|---|---|---|---|---|
| CR or VGPR rateRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 50% | 42% | P=0.10 |
| EFSRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 20% at 7 y | 10% at 7 y | P=0.03 |
| OSRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 42% at 7 y | 21% at 7 y | P=0.01Among patients without a very good partial response within three months of the first transplant, 7-year survival was 11% (single) versus 43% (double) (P<0.001). |
| Endpoint | Analysis | Double transplant | Single transplant | Effect |
|---|---|---|---|---|
| CR or VGPR rateRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 50% | 42% | P=0.10 |
| EFSRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 20% at 7 y | 10% at 7 y | P=0.03 |
| OSRandomised patients (analysis population not stated in the abstract) | primaryAttal 2003 | 42% at 7 y | 21% at 7 y | P=0.01Among patients without a very good partial response within three months of the first transplant, 7-year survival was 11% (single) versus 43% (double) (P<0.001). |