Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study
Phase observationalN = 990
- Population
- Men treated for unilateral testicular cancer between 1980 and 1994 (national follow-up study) (median observation 19 years, range 13 to 28); 74 (8.0%) had atherosclerotic disease during follow-up
- Design
- National follow-up study (2007 to 2008) of men treated for unilateral testicular cancer between 1980 and 1994, grouped by treatment, with 990 age-matched general-population controls (NORMs). Men with cardiovascular disease before or within 2 years after diagnosis were excluded from the cardiovascular endpoints. Age-adjusted Cox regression compared treatment groups with surgery only.
- Arms
- Surgery only (control, n = 206): Surgery without radiotherapy or chemotherapy
- Radiotherapy only (experimental, n = 386): Radiotherapy only
- Chemotherapy only (experimental, n = 364): Chemotherapy only
- Radiotherapy and chemotherapy (experimental, n = 34): Combined radiotherapy and chemotherapy
- People
- Haugnes HS
Atherosclerotic disease after treatmentHR 2.30 (95% CI 1.04–5.30)Atherosclerotic disease after treatmentHR 2.6 (95% CI 1.1–5.9)Atherosclerotic disease after treatmentHR 4.8 (95% CI 1.6–14.4)
Show the numbers
| Endpoint | Analysis | Radiotherapy only / Chemotherapy only / Radiotherapy and chemotherapy | Surgery only | Effect |
|---|---|---|---|---|
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, radiotherapy only versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 2.30 (95% CI 1.04–5.30)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. |
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, chemotherapy only versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 2.6 (95% CI 1.1–5.9)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. The abstract also reports that BEP alone carried a 5.7-fold higher risk of coronary artery disease than surgery only (95% CI 1.9 to 17.1) and a 3.1-fold higher risk of myocardial infarction than the general-population controls (95% CI 1.2 to 7.7). |
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, combined radiotherapy and chemotherapy versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 4.8 (95% CI 1.6–14.4)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. This group had 34 men, hence the wide interval. |
| Endpoint | Analysis | Radiotherapy only / Chemotherapy only / Radiotherapy and chemotherapy | Surgery only | Effect |
|---|---|---|---|---|
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, radiotherapy only versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 2.30 (95% CI 1.04–5.30)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. |
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, chemotherapy only versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 2.6 (95% CI 1.1–5.9)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. The abstract also reports that BEP alone carried a 5.7-fold higher risk of coronary artery disease than surgery only (95% CI 1.9 to 17.1) and a 3.1-fold higher risk of myocardial infarction than the general-population controls (95% CI 1.2 to 7.7). |
| Atherosclerotic disease after treatmentAge-adjusted Cox regression, combined radiotherapy and chemotherapy versus surgery only | finalmedian follow-up 19 yearsHaugnes 2010 | — | — | HR 4.8 (95% CI 1.6–14.4)Hazard ratio for atherosclerotic disease, age-adjusted, compared with surgery only. This group had 34 men, hence the wide interval. |
Data table
| Endpoint | HR | 95% CI |
|---|---|---|
| Atherosclerotic disease after treatment | 2.3 | 1.04–5.3 |
| Atherosclerotic disease after treatment | 2.6 | 1.1–5.9 |
| Atherosclerotic disease after treatment | 4.8 | 1.6–14.4 |