GOG 123
Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma (Gynecologic Oncology Group protocol 123)
- Population
- Women with bulky stage IB cervical cancer (tumour 4 cm or more in diameter); women with lymphadenopathy on CT or lymphangiography were ineligible unless histology showed no lymph-node involvement
- Design
- Randomised comparison of radiotherapy alone or with weekly cisplatin (40 mg/m2, up to six doses, maximum weekly dose 70 mg), followed in all patients by adjuvant hysterectomy three to six weeks later. Cumulative radiation dose was 75 Gy to point A and 55 Gy to point B.
- Arms
- Radiotherapy with weekly cisplatin, then hysterectomy (experimental, n = 183): Pelvic radiotherapy with weekly cisplatin 40 mg/m2 for up to six doses, then adjuvant hysterectomy
- Radiotherapy alone, then hysterectomy (control, n = 186): Pelvic radiotherapy, then adjuvant hysterectomy
- People
- Keys HM, senior author Gersell D, Gynecologic Oncology Group