High-dose chemotherapy and stem-cell rescue for metastatic germ-cell tumors
Phase observationalN = 184
- Population
- Consecutive patients with metastatic testicular cancer progressing after cisplatin-containing chemotherapy; 135 treated second line, 49 third line or later
- Design
- Retrospective review of consecutive patients with metastatic testicular cancer that progressed after cisplatin-containing combination chemotherapy (first-author affiliation Indiana University; the abstract does not state whether a single centre). Not randomised; no control group.
- Arms
- High-dose carboplatin and etoposide with stem-cell rescue (experimental, n = 184): Two consecutive courses (173 patients; 11 received one course) of carboplatin 700 mg per square metre and etoposide 750 mg per square metre, each for 3 days, each followed by autologous peripheral-blood stem cells; 110 patients had vinblastine, ifosfamide and cisplatin first
- People
- Einhorn LH, senior author Abonour R