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Bending the Curve Trial by Trial
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CLASICC

UK MRC CLASICC: Conventional versus Laparoscopic-Assisted Surgery in Colorectal Cancer

N = 794

Population
794 patients with colorectal cancer, colon and rectum together (the abstracts do not separate colon-only counts); 253 and 484 patients actually received open and laparoscopic-assisted treatment.
Design
Multicentre randomised controlled trial in 27 UK centres, July 1996 to July 2002, comparing laparoscopic-assisted with open surgery for colorectal cancer; randomisation 2:1 in favour of laparoscopic-assisted surgery. Primary short-term endpoints: positivity rates of circumferential and longitudinal resection margins, proportion of Dukes' C2 tumours, and in-hospital mortality. Analysis by intention to treat. Registered ISRCTN74883561. Long-term outcomes (3-year and 5-year) were reported later.
Primary endpoint
Resection margin positivity, Dukes' C2 tumours, In-hospital mortality
Arms
  • Open surgery (control, n = 268): Conventional open surgery
  • Laparoscopic-assisted surgery (experimental, n = 526): Laparoscopic-assisted surgery
People
Guillou PJ, UK MRC CLASICC Trial Group
Δ Dukes' C2 tumours−1 pointsΔ In-hospital mortality−1 points
Show the numbers
Results reported for CLASICC
EndpointAnalysisLaparoscopic-assisted surgeryOpen surgeryEffect
Dukes' C2 tumoursITT (as stated in the abstract); patients with colorectal cancer, colon and rectum together (794)primaryGuillou 20056%7%P=0.89Counts as published: 18 patients (7%) open and 34 (6%) laparoscopic; difference -0.3% (95% CI -3.9 to 3.4). Colon and rectal cancer together.
In-hospital mortalityITT (as stated in the abstract); patients with colorectal cancer, colon and rectum together (794)primaryGuillou 20054%5%P=0.57Counts as published: 13 patients (5%) open and 21 (4%) laparoscopic; difference -0.9% (95% CI -3.9 to 2.2). Colon and rectal cancer together.
Results reported for CLASICC
EndpointAnalysisLaparoscopic-assisted surgeryOpen surgeryEffect
Dukes' C2 tumoursITT (as stated in the abstract); patients with colorectal cancer, colon and rectum together (794)primaryGuillou 20056%7%P=0.89Counts as published: 18 patients (7%) open and 34 (6%) laparoscopic; difference -0.3% (95% CI -3.9 to 3.4). Colon and rectal cancer together.
In-hospital mortalityITT (as stated in the abstract); patients with colorectal cancer, colon and rectum together (794)primaryGuillou 20054%5%P=0.57Counts as published: 13 patients (5%) open and 21 (4%) laparoscopic; difference -0.9% (95% CI -3.9 to 2.2). Colon and rectal cancer together.
Primary publication: Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365(9472):1718-26. PubMedDOI

Appears in

Sources

  1. Guillou PJ, Quirke P, Thorpe H, Walker J, Jayne DG, Smith AM, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365(9472):1718-26.

    PubMedDOI