Back to Childhood acute lymphoblastic leukemia (ALL)
References: Childhood acute lymphoblastic leukemia (ALL)
104 sources cited on this page. Links open the primary source.
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Loading… - Frei E 3rd, Karon M, Levin RH, Freireich EJ, Taylor RJ, Hananian J, et al. The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood. 1965;26(5):642-56. PubMedDOI
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Loading… - George P, Hernandez K, Hustu O, Borella L, Holton C, Pinkel D. A study of "total therapy" of acute lymphocytic leukemia in children. J Pediatr. 1968;72(3):399-408. PubMedDOI
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Loading… - Evans AE, Gilbert ES, Zandstra R. The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). Cancer. 1970;26(2):404-9. PubMedDOI
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Loading… - Aur RJ, Simone J, Hustu HO, Walters T, Borella L, Pratt C, et al. Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. Blood. 1971;37(3):272-81. PubMedDOI
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Loading… - Pinkel D. Five-year follow-up of "total therapy" of childhood lymphocytic leukemia. JAMA. 1971;216(4):648-52. PubMedDOI
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Loading… - Pinkel D, Simone J, Hustu HO, Aur RJ. Nine years' experience with "total therapy" of childhood acute lymphocytic leukemia. Pediatrics. 1972;50(2):246-51. PubMedDOI
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Loading… - Simone J, Aur RJ, Hustu HO, Pinkel D. "Total therapy" studies of acute lymphocytic leukemia in children. Current results and prospects for cure. Cancer. 1972;30(6):1488-94. PubMedDOI
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Loading… - Elion GB. The purine path to chemotherapy. Science. 1989;244(4900):41-7. PubMedDOI
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Loading… - Smith M, Arthur D, Camitta B, Carroll AJ, Crist W, Gaynon P, et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol. 1996;14(1):18-24. PubMedDOI
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Loading… - Cavé H, van der Werff ten Bosch J, Suciu S, Guidal C, Waterkeyn C, Otten J, et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group. N Engl J Med. 1998;339(9):591-8. PubMedDOI
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Loading… - Gaynon PS, Qu RP, Chappell RJ, Willoughby ML, Tubergen DG, Steinherz PG, et al. Survival after relapse in childhood acute lymphoblastic leukemia: impact of site and time to first relapse--the Children's Cancer Group Experience. Cancer. 1998;82(7):1387-95. PubMedDOI
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Loading… - Nachman JB, Sather HN, Sensel MG, Trigg ME, Cherlow JM, Lukens JN, et al. Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. N Engl J Med. 1998;338(23):1663-71. PubMedDOI
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Loading… - Relling MV, Rubnitz JE, Rivera GK, Boyett JM, Hancock ML, Felix CA, et al. High incidence of secondary brain tumours after radiotherapy and antimetabolites. Lancet. 1999;354(9172):34-9. PubMedDOI
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Loading… - Coustan-Smith E, Sancho J, Hancock ML, Boyett JM, Behm FG, Raimondi SC, et al. Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia. Blood. 2000;96(8):2691-6. PubMed
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Loading… - European Medicines Agency. Glivec (imatinib): European public assessment report (EPAR) page. Marketing authorisation issued 07/11/2001; page last updated 12/11/2025. Page read 2026-10-20. Source
- Bostrom BC, Sensel MR, Sather HN, Gaynon PS, La MK, Johnston K, et al. Dexamethasone versus prednisone and daily oral versus weekly intravenous mercaptopurine for patients with standard-risk acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood. 2003;101(10):3809-17. PubMedDOI
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Loading… - US Food and Drug Administration. Approval letter, NDA 21-673, Clolar (clofarabine) intravenous infusion, Genzyme Corporation; accelerated approval, 28 December 2004. Source
- Berg SL, Blaney SM, Devidas M, Lampkin TA, Murgo A, Bernstein M, et al. Phase II study of nelarabine (compound 506U78) in children and young adults with refractory T-cell malignancies: a report from the Children's Oncology Group. J Clin Oncol. 2005;23(15):3376-82. PubMedDOI
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Loading… - US Food and Drug Administration. Approval letter, Arranon (nelarabine) injection, NDA 21-877, GlaxoSmithKline. Electronic signature date 28 October 2005. Source
- Avramis VI, Tiwari PN. Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia. Int J Nanomedicine. 2006;1(3):241-54. PubMed
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Loading… - European Medicines Agency. Sprycel (dasatinib): European public assessment report (EPAR) page. Marketing authorisation issued 20/11/2006; page last updated 02/10/2026. Page read 2026-10-20. Source
- U.S. Food and Drug Administration. Approval letter, STN BL 103411/5052, pegaspargase (Oncaspar), supplement expanding the indication to first-line multi-agent treatment of acute lymphoblastic leukemia, 2006. Source
- Miller DR. A tribute to Sidney Farber-- the father of modern chemotherapy. Br J Haematol. 2006;134(1):20-6. PubMedDOI
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Loading… - Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446(7137):758-64. PubMedDOI
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Loading… - Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007;370(9583):240-250. PubMedDOI
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Loading… - Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, et al. Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study. Blood. 2008;111(12):5477-85. PubMedDOI
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Loading… - Mody R, Li S, Dover DC, Sallan S, Leisenring W, Oeffinger KC, et al. Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Blood. 2008;111(12):5515-23. PubMedDOI
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Loading… - Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med. 2009;360(5):470-80. PubMedDOI
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Loading… - Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med. 2009;360(26):2730-41. PubMedDOI
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Loading… - Schultz KR, Bowman WP, Aledo A, Slayton WB, Sather H, Devidas M, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a children's oncology group study. J Clin Oncol. 2009;27(31):5175-81. PubMedDOI
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Loading… - Aricò M, Schrappe M, Hunger SP, Carroll WL, Conter V, Galimberti S, et al. Clinical outcome of children with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia treated between 1995 and 2005. J Clin Oncol. 2010;28(31):4755-61. PubMedDOI
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Loading… - Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grümayer R, Möricke A, et al. Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood. 2010;115(16):3206-14. PubMedDOI
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Loading… - Parker C, Waters R, Leighton C, Hancock J, Sutton R, Moorman AV, et al. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet. 2010;376(9757):2009-17. PubMedDOI
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Loading… - Biondi A, Schrappe M, De Lorenzo P, Castor A, Lucchini G, Gandemer V, et al. Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study. Lancet Oncol. 2012;13(9):936-45. PubMedDOI
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Loading… - Hunger SP, Lu X, Devidas M, Camitta BM, Gaynon PS, Winick NJ, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children's oncology group. J Clin Oncol. 2012;30(14):1663-9. PubMedDOI
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Loading… - Spain PD, Kadan-Lottick N. Observations of unprecedented remissions following novel treatment for acute leukemia in children in 1948. J R Soc Med. 2012;105(4):177-81. PubMedDOI
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Loading… - US Food and Drug Administration. Supplement approval letter, Gleevec (imatinib mesylate) tablets, NDA 021588/S-037, Novartis Pharmaceuticals Corporation. Electronic signature date 25 January 2013. Source
- Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368(16):1509-1518. PubMedDOI
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Loading… - Pui CH, Evans WE. A 50-year journey to cure childhood acute lymphoblastic leukemia. Semin Hematol. 2013;50(3):185-96. PubMedDOI
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Loading… - Vora A, Goulden N, Wade R, Mitchell C, Hancock J, Hough R, et al. Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial. Lancet Oncol. 2013;14(3):199-209. PubMedDOI
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Loading… - Buitenkamp TD, Izraeli S, Zimmermann M, Forestier E, Heerema NA, van den Heuvel-Eibrink MM, et al. Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group. Blood. 2014;123(1):70-7. PubMedDOI
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Loading… - Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371(16):1507-1517. PubMedDOI
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Loading… - Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med. 2014;371(11):1005-15. PubMedDOI
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Loading… - Schultz KR, Carroll A, Heerema NA, Bowman WP, Aledo A, Slayton WB, et al. Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group study AALL0031. Leukemia. 2014;28(7):1467-71. PubMedDOI
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Loading… - European Medicines Agency. Blincyto: EPAR page (conditional marketing authorisation 23 November 2015, standard authorisation 18 June 2018; page lists an update dated 22 September 2026). Accessed 20 October 2026. Source
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Loading… - US Food and Drug Administration. BLA 125557/S-005 and S-006 supplement approval letter, Blincyto (blinatumomab), Amgen; 30 August 2016. Source
- Larsen EC, Devidas M, Chen S, Salzer WL, Raetz EA, Loh ML, et al. Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group Study AALL0232. J Clin Oncol. 2016;34(20):2380-8. PubMedDOI
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Loading… - von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, et al. Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. J Clin Oncol. 2016;34(36):4381-4389. PubMedDOI
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Loading… - European Medicines Agency. Besponsa: EPAR page (marketing authorisation issued 28 June 2017; page lists an update dated 18 May 2026). Accessed 20 October 2026. Source
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- US Food and Drug Administration. BLA approval letter, STN 125646/0, tisagenlecleucel (Kymriah), Novartis Pharmaceuticals Corporation; 30 August 2017. Source
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Loading… - European Medicines Agency. Kymriah: EPAR page (marketing authorisation issued 23 August 2018; page lists an update dated 1 September 2026). Accessed 20 October 2026. Source
- US Food and Drug Administration. BLA 125557/S-013 accelerated approval letter, Blincyto (blinatumomab), Amgen; 29 March 2018. Source
- US Food and Drug Administration. Supplement approval letter, Sprycel (dasatinib) tablets, NDA 021986/S-021, Bristol-Myers Squibb Company. Electronic signature date 21 December 2018. Source
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Loading… - Slayton WB, Schultz KR, Kairalla JA, Devidas M, Mi X, Pulsipher MA, et al. Dasatinib Plus Intensive Chemotherapy in Children, Adolescents, and Young Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of Children's Oncology Group Trial AALL0622. J Clin Oncol. 2018;36(22):2306-2314. PubMedDOI
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Loading… - US Food and Drug Administration. Supplement approval letter (fulfillment of postmarketing requirement), Arranon (nelarabine) injection, NDA 021877/S-010, Novartis Pharmaceuticals Corporation. Electronic signature date 31 July 2019. Source
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Loading… - Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, et al. Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study. J Clin Oncol. 2019;37(25):2246-2256. PubMedDOI
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Loading… - Dunsmore KP, Winter SS, Devidas M, Wood BL, Esiashvili N, Chen Z, et al. Children's Oncology Group AALL0434: A Phase III Randomized Clinical Trial Testing Nelarabine in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia. J Clin Oncol. 2020;38(28):3282-3293. PubMedDOI
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Loading… - Shen S, Chen X, Cai J, Yu J, Gao J, Hu S, et al. Effect of Dasatinib vs Imatinib in the Treatment of Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA Oncol. 2020;6(3):358-366. PubMedDOI
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Loading… - Angiolillo AL, Schore RJ, Kairalla JA, Devidas M, Rabin KR, Zweidler-McKay P, et al. Excellent Outcomes With Reduced Frequency of Vincristine and Dexamethasone Pulses in Standard-Risk B-Lymphoblastic Leukemia: Results From Children's Oncology Group AALL0932. J Clin Oncol. 2021;39(13):1437-1447. PubMedDOI
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Loading… - Brivio E, Locatelli F, Lopez-Yurda M, Malone A, Díaz-de-Heredia C, Bielorai B, et al. A phase 1 study of inotuzumab ozogamicin in pediatric relapsed/refractory acute lymphoblastic leukemia (ITCC-059 study). Blood. 2021;137(12):1582-1590. PubMedDOI
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Loading… - Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, et al. Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2021;325(9):833-842. PubMedDOI
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Loading… - Locatelli F, Zugmaier G, Rizzari C, Morris JD, Gruhn B, Klingebiel T, et al. Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. JAMA. 2021;325(9):843-854. PubMedDOI
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Loading… - Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, et al. Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial. J Clin Oncol. 2023;41(9):1664-1669. PubMedDOI
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