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Bending the Curve Trial by Trial
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Author of the 1989 Cain Memorial Award lecture on the oxazaphosphorine cytostatics, Co-author of a 1958 note on cyclic N-lost-phosphamide esters as new cancer chemotherapeutics

Norbert Brock

Author of the 1989 Cancer Research lecture describing the design of cyclophosphamide, ifosfamide and trofosfamide, and third author of a 1958 note on new cancer chemotherapeutics from the group of cyclic N-lost-phosphamide esters. A 2023 history names him among those whose contributions led to the oxazaphosphorines.

Sources

  1. Brock N. Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture. Cancer Res. 1989;49(1):1-7.

    PubMed

  2. Arnold H, Bourseaux F, Brock N. Neuartige Krebs-Chemotherapeutika aus der Gruppe der zyklischen N-Lost-Phosphamidester. Die Naturwissenschaften. 1958;45(3):64-66.

    DOI

  3. Idle JR, Beyoğlu D. Ifosfamide - History, efficacy, toxicity and encephalopathy. Pharmacol Ther. 2023;243:108366.

    PubMedDOI