Led the Cancer Research Campaign group in which temozolomide and mitozolomide were developed; first author of the 1984 report on antitumour imidazotetrazines
Malcolm F. G. Stevens
University of Nottingham (Emeritus Professor in 2023); Aston University (site of the imidazotetrazine work)
First author of the 1984 Journal of Medicinal Chemistry paper on the synthesis and chemistry of the antitumour imidazotetrazine mitozolomide and, with Richard Wheelhouse, of a 2023 review of the imidazotetrazines. The review's biography describes him as Emeritus Professor at the University of Nottingham, from whose laboratory five new molecules have entered clinical trials, and Wheelhouse's biography describes the Cancer Research Campaign group led by Stevens at Aston and Nottingham Universities.
Sources
Stevens MFG, Wheelhouse RT. Antitumour imidazotetrazines: past, present… and future?. RSC Chem Biol. 2023;4(10):736-741.
Stevens MF, Hickman JA, Stone R, Gibson NW, Baig GU, Lunt E, et al. Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent. J Med Chem. 1984;27(2):196-201.