Investigator of combination antimetabolite studies in leukemia
Emil Frei III
National Cancer Institute, National Institutes of Health
First author of the 1961 and 1965 reports in Blood that compared mercaptopurine and methotrexate, alone and in combination, in acute leukemia. Crossref lists his affiliation on both papers as the National Cancer Institute (the 1965 record gives the Medicine Branch, with a later address at the University of Texas M. D. Anderson Hospital and Tumor Institute).
Milestones
Sources
Frei E 3rd, Freireich EJ, Gehan E, Pinkel D, Holland JF, Selawry O, et al. Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate. Blood. 1961;18(4):431-54.
Frei E 3rd, Karon M, Levin RH, Freireich EJ, Taylor RJ, Hananian J, et al. The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood. 1965;26(5):642-56.