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First author of the 1984 report of polyethylene glycol-asparaginase conjugates in mice

A. Abuchowski

First author of a 1984 report that attaching polyethylene glycol to E. coli and Vibrio succinogenes asparaginases gave active, stable conjugates with greatly extended half-lives in mice, and an author of a 1981 report of the PEG adduct given to four patients and of a 1986 clinical pharmacology study. Only the initial is given in the sources read.

Sources

  1. Abuchowski A, Kazo GM, Verhoest CR Jr, Van Es T, Kafkewitz D, Nucci ML, et al. Cancer therapy with chemically modified enzymes. I. Antitumor properties of polyethylene glycol-asparaginase conjugates. Cancer Biochem Biophys. 1984;7(2):175-86.

    PubMed

  2. Park YK, Abuchowski A, Davis S, Davis F. Pharmacology of Escherichia coli-L-asparaginase polyethylene glycol adduct. Anticancer Res. 1981;1(6):373-6.

    PubMed

  3. Ho DH, Brown NS, Yen A, Holmes R, Keating M, Abuchowski A, et al. Clinical pharmacology of polyethylene glycol-L-asparaginase. Drug Metab Dispos. 1986;14(3):349-52.

    PubMed